• The nuclear receptor liver X receptor LXR represents a

  2019-04-28

  

  The nuclear receptor liver X receptor (LXR) represents a promising therapeutic target for bile find out this here detoxification by enhancing the metabolism and elimination of bile acids as well as by reducing inflammation. Both pharmacological stimulation and genetic activation of LXR prevented LC

• br Introduction Since Reekers and Bolia introduced subintima

  2019-04-28

  

  Introduction Since Reekers and Bolia introduced subintimal angioplasty, the trans-subintimal route has become the preferred technique to advance the guidewire through a totally occluded and often heavily calcified lesion, especially in the aortoiliac segment. The technical failure was seen in 20–

• Amiodarone has been used in Japan for more than

  2019-04-28

  

  Amiodarone has been used in Japan for more than 5 years now since its approval in July 2007, and intravenous amiodarone has been widely used for life-threatening ventricular tachycardia in the setting of critical care medicine. However, only few reports have been published in the international liter

• 5 alpha reductase Fig shows the percentage of patients

  2019-04-28

  

  Fig. 2 shows the percentage of patients with high D-dimer levels in relation to the CHA2DS2–VASc scores and BNP levels. None of the patients had a CHA2DS2–VASc score of 0. The BNP levels were elevated in 3 (38%) of the 8 patients with CHA2DS2–VASc scores of 1, and the D-dimer levels were elevated in

• Bisphosphonates are a well established standard of

  2019-04-28

  

  Bisphosphonates are a well-established, standard-of care treatment option to reduce the frequency and severity and time of onset of the skeletal related events (SREs) in patients with bone metastases due to either solid tumours or multiple myeloma [21–33]. From many years, BPs have been incorporated

• Both breast cancer and MM cause

  2019-04-28

  

  Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit

• In Jillian Pintye and colleagues from the Partners PrEP stud

  2019-04-28

  

  In Jillian Pintye and colleagues from the Partners PrEP study team present one of the largest and most comprehensive analyses of syphilis incidence in men and women and the effect of male circumcision. The investigators followed 4716 HIV-1 serodiscordant couples, of whom roughly 50% of the men were

• In the past three decades along with rapid

  2019-04-28

  

  In the past three decades, along with rapid economic growth in China, there has been a striking increase in alcohol consumption, greater than in most other parts of the world (). Although the melanocortin receptor drinking level in China used to be far lower than in many high-income and middle-inco

• br Las fuerzas Impulsoras de la

  2019-04-28

  

  Las fuerzas Impulsoras de la Internacionalización de la ciencia y la technología en América latina Los eLementos indicativos de la internacionalizacion de la ciencia y la tecnología en América Latina Debates ytensiones en torno de la internacionalización de la ciencia y la technología en Amé

• Un tercer gui n si acaso el

  2019-04-28

  

  Un tercer guión, si acaso el más inquietante de los tres, podría hallarse en la banda de cuatro críticos literarios consagrados hcv virus la obra de Archimboldi, el gran autor que Bolaño introduce en la novela 2666. La narración capta una muestra episódica del modo de inserción del intelectual acadé

• El n mero de correspondiente al segundo semestre de

  2019-04-28

  

  El número 59 de , correspondiente al segundo semestre de 2014, ofrece la sección Temas y Problemas de Nuestra América, en el que se encuentran artículos relacionados con asuntos de gran relevancia actual. En primer lugar, el texto “Nuevas narrativas constitucionales en Bolivia y Ecuador: el buen viv

• LYL belongs to the basic

  2019-04-28

  

  LYL1 belongs to the basic helix-loop-helix (bHLH) transcription factor family, which plays important roles in a variety of developmental processes, including hematopoiesis [6]. The biological function of LYL1 is largely unknown, but its expression is restricted to hematopoietic cells, including mye

• br The study by Jesse Berman and

  2019-04-28

  

  The study by Jesse Berman and colleagues published in is the first to systematically analyse the risk of hospital admissions and mortality associated with drought periods in the USA. As the authors state, this is an understudied topic, but of great concern in the USA and globally as climate chang

• Cyclic AMP cAMP is a key factor involved in the

  2019-04-26

  

  Cyclic AMP (cAMP) is a key factor involved in the signal transduction pathways of melanogenesis. CREB, a cellular transcription factor, can be activated by the cAMP signaling pathway through protein kinase A (PKA). PKA is an important group of Ser/Thr kinase family and can phosphorylate CREB (p-CREB

• Amongst other anti arrhythmic medications disopyramide class

  2019-04-26

  

  Amongst other anti-arrhythmic medications, disopyramide (class 1A AAM) has anticholinergic side effects such as dry mouth, urinary hesitancy, constipation and exacerbation of conditions like glaucoma and myasthenia gravis. Disopyramide acts by targeting the fast sodium Rosiglitazone cost in the car

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